Non-Surgical

Polynucleotides

Polynucleotides are injectable biostimulators that repair and regenerate skin at a cellular level — improving hydration, elasticity and overall skin quality.

Your Trusted Partner in Aesthetics

Profile Aesthetic is a medically-led clinic in Aberdeen serving the Northeast of Scotland. Our Specialist Aesthetic Nurses deliver polynucleotide treatments within a structured skin-health plan, using evidence-informed protocols for deep skin regeneration.

Why Choose Polynucleotides?

Polynucleotides are chosen when the goal is deep skin repair and regeneration rather than volume or reshaping. These injectable biostimulators are derived from purified DNA fragments that stimulate fibroblast activity, promote tissue repair and improve hydration at a cellular level. They're particularly effective for skin that has lost its resilience — whether from ageing, sun damage or scarring.

Unlike hyaluronic acid fillers, polynucleotides don't add volume. Instead, they work by improving the skin's own regenerative capacity, making them a good option for patients wanting genuine skin quality improvement from within.

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Procedure Details

Polynucleotides are injected into the treatment area using fine needles or a cannula, depending on the area and technique. The product integrates into the tissue and stimulates fibroblast activity — the cells responsible for producing collagen and elastin. Your clinician tailors the injection pattern and depth to your specific concerns. A course of 2–3 sessions is typically recommended, spaced 3–4 weeks apart.

Before the Procedure

  • Avoid alcohol for 24 hours if possible
  • Tell us about: allergies, autoimmune conditions, pregnancy/breastfeeding, active skin infections
  • Pause retinoids or strong actives if advised
  • Arrive with clean skin if possible

During the Procedure

  • Typically 20–30 minutes
  • A series of small injections across the treatment area
  • Mild discomfort — most patients tolerate it well
  • Topical numbing can be applied if needed

After the Procedure

  • Small bumps at injection sites are normal and usually settle within hours
  • Mild redness or bruising is possible
  • Avoid heat, strenuous exercise and make-up for 24 hours
  • Follow your tailored aftercare guidance
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At a Glance

Anaesthesia
None or Topical
Procedure
20-30 min
No. of Treatments
2-3 sessions, 3-4 weeks apart
Downtime
Minimal
Discomfort
Mild
Sports
24h
Results
4-8 weeks
Maintenance
Every 6-12 months

Frequently asked questions

Everything you need to know about  
Polynucleotides
Does Polynucleotides hurt?
Polynucleotides is comfortable for most people, with only mild discomfort. It is performed without anaesthetic, or with topical numbing cream if you prefer.

Polynucleotides is comfortable for most people, with only mild discomfort. It is performed without anaesthetic, or with topical numbing cream if you prefer. A treatment takes around 20–30 min, and your practitioner will keep you comfortable throughout.

Is there any downtime after Polynucleotides?
Polynucleotides typically involves minimal downtime, with a return to exercise after about 24 hours.

Polynucleotides typically involves minimal downtime. You can usually return to exercise after about 24 hours.

How many Polynucleotides sessions will I need, and when will I see results?
We usually recommend 2–3 sessions, 3–4 weeks apart; results are typically seen from around 4–8 weeks.

For the best result we usually recommend 2–3 sessions, 3–4 weeks apart. Results are typically seen from around 4–8 weeks.

How long do Polynucleotides results last?
Results are not permanent; typical maintenance: Every 6–12 months.

Polynucleotides results last well but are not permanent. Typical maintenance: Every 6–12 months. Your practitioner will tailor this to your goals at your consultation.

We cater to your unmet needs and desires.

Ready for your unique journey?